This man couldn't understand why I was going through this Coumadin fear after 10 years of use. I got a pat on the back and a trust your doctor's lecture. I got a pat on the back and a trust your doctor's lecture. Coumadin ® is indicated for: • Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). • Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. Coumadin (warfarin) is a blood anticoagulant that inhibits the function of Vitamin K dependent coagulation used to inhibit the coagulation of blood to reduce or prevent the chance of developing heart attacks (myocardial infarctions), strokes, and venous and other blood clots (deep venous thromboses, pulmonary emboli and thrombi produced with. Warfarin exerts its anticoagulant action by interfering with the vitamin K mediated synthesis of clotting factors in the liver. Hepatic synthetic function is maximum at night. I recently had a severe and dangerous reaction to the bloodthinng medication xarelto after developing a clot in my left leg. I was hospitalized and given coumadin instead and have been ttrapidly improving, no complications. Sometimes I forget to take it at bedtime as directed. Is there any specific reason that you should only take it. Take your Coumadin at the same time every day (usually before bedtime) Eat the same amount of vitamin K containing food every day (e.g., fish, broccoli, spinach, cabbage, kale, cauliflower) Avoid excessive alcohol Due to atrial fibrillation, I have been taking Coumadin for 3 years. When I filled a new prescription for the Coumadin, the directions said take at bedtime. This is a comment to the admin. I came to your “Why Coumadin is given in the evening or night? sajerosablog” page via Google but it was hard to find as you were not on the first page of search results. How to use Coumadin. Read the Medication Guide provided by your pharmacist before you start taking warfarin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Coumadin® is always taken ONCE A DAY AT BEDTIME. There are several reasons for this: There are several reasons for this: The medication is released over 24 hours, and taking it at the same time will keep your blood level stable.